UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 6 von 45
Datensatz exportieren als...
BibTeX
Surface modification of neural recording electrodes with conducting polymer/biomolecule blends
Journal of biomedical materials research, 2001-08, Vol.56 (2), p.261-272
Cui, Xinyan
Lee, Valerie A.
Raphael, Yehoash
Wiler, James A.
Hetke, Jamille F.
Anderson, David J.
Martin, David C.
2001
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Cui, Xinyan
Lee, Valerie A.
Raphael, Yehoash
Wiler, James A.
Hetke, Jamille F.
Anderson, David J.
Martin, David C.
Titel
Surface modification of neural recording electrodes with conducting polymer/biomolecule blends
Ist Teil von
Journal of biomedical materials research, 2001-08, Vol.56 (2), p.261-272
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2001
Quelle
MEDLINE
Beschreibungen/Notizen
The interface between micromachined neural microelectrodes and neural tissue plays an important role in chronic in vivo recording. Electrochemical polymerization was used to optimize the surface of the metal electrode sites. Electrically conductive polymers (polypyrrole) combined with biomolecules having cell adhesion functionality were deposited with great precision onto microelectrode sites of neural probes. The biomolecules used were a silk‐like polymer having fibronectin fragments (SLPF) and nonapeptide CDPGYIGSR. The existence of protein polymers and peptides in the coatings was confirmed by reflective microfocusing Fourier transform infrared spectroscopy (FTIR). The morphology of the coating was rough and fuzzy, providing a high density of bioactive sites for interaction with neural cells. This high interfacial area also helped to lower the impedance of the electrode site and, consequently, to improve the signal transport. Impedance spectroscopy showed a lowered magnitude and phase of impedance around the biologically relevant frequency of 1 kHz. Cyclic voltammetry demonstrated the intrinsic redox reaction of the doped polypyrrole and the increased charge capacity of the coated electrodes. Rat glial cells and human neuroblastoma cells were seeded and cultured on neural probes with coated and uncoated electrodes. Glial cells appeared to attach better to polypyrrole/SLPF‐coated electrodes than to uncoated gold electrodes. Neuroblastoma cells grew preferentially on and around the polypyrrole/CDPGYIGSR‐coated electrode sites while the polypyrrole/CH3COO−‐coated sites on the same probe did not show a preferential attraction to the cells. These results indicate that we can adjust the chemical composition, morphology, electronic transport, and bioactivity of polymer coatings on electrode surfaces on a multichannel micromachined neural probe by controlling electrochemical deposition conditions. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 261–272, 2001
Sprache
Englisch
Identifikatoren
ISSN: 0021-9304
eISSN: 1097-4636
DOI: 10.1002/1097-4636(200108)56:2<261::AID-JBM1094>3.0.CO;2-I
Titel-ID: cdi_proquest_miscellaneous_70816493
Format
–
Schlagworte
Animals
,
Biocompatible Materials
,
Biological and medical sciences
,
Biopolymers - chemistry
,
Cell Adhesion - drug effects
,
cell attachment
,
Cells, Cultured
,
conducting polymers
,
Electrochemistry
,
Humans
,
Investigative techniques, diagnostic techniques (general aspects)
,
Medical sciences
,
Microelectrodes
,
Microscopy, Electron, Scanning
,
Miscellaneous. Technology
,
neural microelectrode
,
Oxidation-Reduction
,
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
,
Polymers - chemistry
,
Pyrroles - chemistry
,
Rats
,
Silicon - chemistry
,
Spectroscopy, Fourier Transform Infrared
,
surface modification
,
Surface Properties
,
Tumor Cells, Cultured
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX