Details

Autor(en) / Beteiligte

• Knopp, M.V.
• Weiss, E.
• Sinn, H.P.
• Mattern, J.
• Junkermann, H.
• Radeleff, J.
• Magener, A.
• Brix, G.
• Delorme, S.
• Zuna, I.
• van Kaick, G.

Titel

Pathophysiologic basis of contrast enhancement in breast tumors

Ist Teil von

• Journal of magnetic resonance imaging, 1999-09, Vol.10 (3), p.260-266

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• While the diagnostic benefits of gadolinium (Gd)‐chelate contrast agents are firmly established in magnetic resonance imaging (MRI) of tumors, the pathophysiologic basis of the enhancement observed and its histopathologic correlate remained vague. Tumor angiogenesis is fundamental for growth and metastasis and also of interest in new therapeutic concepts. By correlative analysis of a) histology; b) vascular density (CD31); and c) vascular permeability (vascular permeability factor/vascular endothelial growth factor [VPF/VEGF]), we found a) significantly (P < 0.001) faster exchange rates in malignant compared with benign breast lesions; b) distinct differences in enhancement characteristics between the histologic types (invasive ductal carcinoma, invasive lobular carcinoma, and ductal carcinoma in situ); and c) dependence of enhancement kinetics on the VPF/VEGF expression. The pathophysiologic basis for the differences in contrast enhancement patterns of tumors detectable by MRI is mainly due to vascular permeability, which leads to more characteristic differences than vascular density. MRI is able to subclassify malignant breast tumors due to their different angiogenetic properties. J. Magn. Reson. Imaging 1999;10:260–266. © 1999 Wiley‐Liss, Inc.