Details

Autor(en) / Beteiligte

• Harada, Shuko, MD
• Kalla, Hari, MD
• Balasubramanian, Manjula, MD
• Brodsky, Isadore, MD
• Gladstone, Douglas, MD
• Hou, J. Steve, MD

Titel

Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen

Ist Teil von

• Annals of diagnostic pathology, 2008-06, Vol.12 (3), p.212-216

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Combination of the splenic marginal zone B-cell lymphoma (SMZL) and classical Hodgkin lymphoma (cHL) is extremely rare. We report a unique case with concurrent SMZL and cHL. The patient was a 63-year-old man who presented with fatigue and anemia, showing a splenomegaly and retroperitoneal lymphadenopathy. A splenectomy revealed monotonous marginal zone lymphocytic infiltrates and numerous large Reed-Sternberg–like cells. Flow cytometry revealed a κ light-chain–restricted CD5 (−), CD23 (−) B-cell population. DNA polymerase chain reaction analysis confirmed the presence of clonal rearrangement of the immunoglobulin heavy-chain gene. Immunohistochemical studies revealed that the large atypical cells were CD30 (+), CD15 (weakly +), CD20 (−), CD45 (−), Pax5 (weakly +), BOB.1 (−), and Oct2 (−), indicating the coexistence of SMZL with cHL. After the chemotherapy, the patient achieved a clinical/radiologic remission, whereas cHL was detected in liver and bone marrow subsequently. The case indicates that both components of lymphoma can present concurrently as a composite form of lymphoma and both need to be treated adequately.