Details

Autor(en) / Beteiligte

• Cook, Matthew J
• Rovis, Tomislav

Titel

Rhodium-Catalyzed Enantioselective Desymmetrization of meso-3,5-Dimethyl Glutaric Anhydride:  A General Strategy to syn-Deoxypolypropionate Synthons

Ist Teil von

• Journal of the American Chemical Society, 2007-08, Vol.129 (30), p.9302-9303

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• A rhodium phosphinooxazoline system allows for an efficient enantioselective desymmetrization of dimethyl glutaric anhydride. Both commercially available and in situ generated sp3-organozinc nucleophiles couple efficiently in high enantiomeric excess. This chemistry has also been extended to other 3,5-disubstituted anhydrides, and further elaboration has enabled the synthesis of potentially useful syn-deoxypolypropionate fragments.