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Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer
British journal of surgery, 2007-08, Vol.94 (8), p.984-991
Setoyama, T.
Natsugoe, S.
Okumura, H.
Matsumoto, M.
Uchikado, Y.
Aikou, T.
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Setoyama, T.
Natsugoe, S.
Okumura, H.
Matsumoto, M.
Uchikado, Y.
Aikou, T.
Titel
Isolated tumour cells in blood and E-cadherin expression in oesophageal squamous cell cancer
Ist Teil von
British journal of surgery, 2007-08, Vol.94 (8), p.984-991
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2007
Quelle
MEDLINE
Beschreibungen/Notizen
Background: Patients with oesophageal squamous cell carcinoma have a high rate of recurrence, even after curative resection. The aim of this study was to examine the correlation between the presence of isolated tumour cells (ITCs) in the blood and recurrence, and between the presence of ITCs and E‐cadherin expression in the primary tumour in these patients. Methods: Blood samples obtained immediately before and after resection in 125 patients with oesophageal squamous cell carcinoma were examined by real‐time reverse transcription–polymerase chain reaction using carcinoembryonic antigen mRNA. Blood samples from 28 healthy volunteers and 42 patients with benign diseases were used as controls. Results: Seventy‐seven patients (61·6 per cent) were ITC positive. ITC positivity correlated significantly with tumour depth, lymph node metastasis, stage, lymphatic invasion and venous invasion. Multivariable analysis revealed that tumour depth and ITC positivity were independent factors for a shortened haematogenous disease‐free interval. A significant correlation was found between ITC positivity and reduced E‐cadherin expression in the primary tumour (P < 0·001). ITC‐positive patients with preserved E‐cadherin expression had a longer disease‐free interval (P = 0·016), haematogenous disease‐free interval (P = 0·020) and overall survival (P = 0·004) than those with reduced E‐cadherin expression. Conclusion: Examination of ITCs in the blood is useful for predicting haematogenous recurrence in patients with oesophageal squamous cell carcinoma. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Bad prognosis with detectable tumour cells in the bloodstream
Sprache
Englisch
Identifikatoren
ISSN: 0007-1323
eISSN: 1365-2168
DOI: 10.1002/bjs.5717
Titel-ID: cdi_proquest_miscellaneous_70751475
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Cadherins - metabolism
,
Carcinoembryonic Antigen - metabolism
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - pathology
,
Carcinoma, Squamous Cell - surgery
,
Esophageal Neoplasms - metabolism
,
Esophageal Neoplasms - pathology
,
Esophageal Neoplasms - surgery
,
Esophagus
,
Female
,
Gastroenterology. Liver. Pancreas. Abdomen
,
General aspects
,
Humans
,
Male
,
Medical sciences
,
Middle Aged
,
Neoplasm Recurrence, Local - metabolism
,
Neoplasm Recurrence, Local - pathology
,
Neoplastic Cells, Circulating
,
Reverse Transcriptase Polymerase Chain Reaction
,
RNA, Messenger - metabolism
,
Survival Analysis
,
Tumor Cells, Cultured
,
Tumors
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