Behavioural brain research, 2006-03, Vol.168 (1), p.172-175
2006
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- Autor(en) / Beteiligte
- Titel
- Social behavior deficits in the Fmr1 mutant mouse
- Ist Teil von
- Behavioural brain research, 2006-03, Vol.168 (1), p.172-175
- Ort / Verlag
- Shannon: Elsevier B.V
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2 min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-4328eISSN: 1872-7549DOI: 10.1016/j.bbr.2005.11.004Titel-ID: cdi_proquest_miscellaneous_70722713
- Format
- –
- Schlagworte
- Animals, Autism, Autistic Disorder - psychology, BALB/cJ, Biological and medical sciences, C57BL/6J, Child clinical studies, DBA/2J, Developmental disorders, Female, Fmr1 KO, Fragile X Mental Retardation Protein - genetics, Fragile X Syndrome, Habituation, Psychophysiologic - physiology, Infantile autism, Interpersonal Relations, Medical sciences, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mouse model of autism, Mutation - genetics, Mutation - physiology, Ovariectomy, Pilot Projects, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Social Behavior, Social Environment, Species Specificity