Details

Autor(en) / Beteiligte

• Thakurdas, Shakeel M.
• Melicoff, Ernestina
• Sansores-Garcia, Leticia
• Moreira, Daniel C.
• Petrova, Youlia
• Stevens, Richard L.
• Adachi, Roberto

Titel

The Mast Cell-restricted Tryptase mMCP-6 Has a Critical Immunoprotective Role in Bacterial Infections

Ist Teil von

• The Journal of biological chemistry, 2007-07, Vol.282 (29), p.20809-20815

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Although it has been shown that mast cell-deficient mice have diminished innate immune responses against bacteria, the most important immunoprotective factors secreted from activated mast cells have not been identified. Mouse mast cell protease 6 is a tetramer-forming tryptase. This serine protease is abundant in the secretory granules and is exocytosed upon bacterial challenge. Here we have described the generation of a mast cell protease-6-null mouse. Our discovery that mice lacking this neutral protease cannot efficiently clear Klebsiella pneumoniae from their peritoneal cavities reveals an essential role for this serine protease, and presumably its human ortholog, in innate immunity.