Details

Autor(en) / Beteiligte

• Ghazanfari, Tooba
• Hassan, Zuhair M.
• Khamesipour, Ali

Titel

Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic ( Allium Sativum) treatment

Ist Teil von

• Journal of ethnopharmacology, 2006-02, Vol.103 (3), p.333-337

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2006

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• It has been shown that garlic ( Allium sativum) extract modulates immune responses. Macrophage activation is required to establish control of the intracellular infection and progressive disease of leishmaniasis. In this study, we consider the effect of a garlic extract and a fraction isolated from it on the engulfment and destruction of Leishmania major by resident peritoneal macrophages of Balb/ c mice. In regard to this study, the infiltration of macrophages in the peritoneal cavity after garlic treatment and the rate of amastigotes per macrophage were determined. The results show that a single dose of 20 mg/kg garlic extract intraperitoneally (i.p.) alters the number of peritoneal macrophages for at least 2 weeks. Intraperitoneal injection of garlic extract (20 mg/kg) or its protein fraction (0.04 mg/kg) augments parasite engulfment and destruction of intracellular amastigotes by macrophages.