Details

Autor(en) / Beteiligte

• STONE, Jennifer
• GURRIN, Lyle C
• BYMES, Graham B
• SCHROEN, Christopher J
• TRELOAR, Susan A
• PADILLA, Emma J. D
• DITE, Gillian S
• SOUTHEY, Melissa C
• HAYES, Vanessa M
• HOPPER, John L

Titel

Mammographic Density and Candidate Gene Variants: A Twins and Sisters Study

Ist Teil von

• Cancer epidemiology, biomarkers & prevention, 2007-07, Vol.16 (7), p.1479-1484

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Mammographic density, the light/white radiographic appearance on a mammogram that represents connective and epithelial tissue, is a strong risk factor for breast cancer which seems to be highly heritable. Little is known about its genetic determinants. Methods: We studied 457 women from 207 sisterhoods (104 monozygotic twins, 182 dizygotic twins, and 171 singletons). Percentage mammographic density (PMD) as well as dense area and nondense area were calculated using a computer-assisted method. We measured six single nucleotide polymorphisms from six candidate genes ( COMT, HSD3B1, IGFBP3, HER2, XPD , and XRCC3 ). Associations between genotypes and mammographic measures were tested ( a ) cross-sectionally using a multivariate normal model fitted using FISHER that allowed separate correlations for monozygotic, dizygotic, and nontwin pairs and ( b ) within sister pairs using paired t tests. Results: Cross-sectionally, each additional copy of the HSD3B1 Asn 367 Thr variant allele was associated with lower PMD (−3.47% per allele; SE = 1.65; P = 0.035). Within-pair regression estimates confirmed this association. There was no evidence for an association between the mammographic density measures and any of the other variants studied. Conclusion: We have replicated an association between a variant in the HSD3B1 gene and PMD, which suggests that HSD3B1 may be genetic determinant of mammographic density. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1479–84)