Cancer research (Chicago, Ill.), 2007-07, Vol.67 (13), p.5999-6002
2007
Details
- Autor(en) / Beteiligte
- Titel
- Nuclear and cytoplasmic survivin : Molecular mechanism, prognostic, and therapeutic potential
- Ist Teil von
- Cancer research (Chicago, Ill.), 2007-07, Vol.67 (13), p.5999-6002
- Ort / Verlag
- Philadelphia, PA: American Association for Cancer Research
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in the front line of cancer research. Notably, survivin is detected as a cytoplasmic and nuclear protein in cancer patients, which stimulated numerous studies to investigate and to speculate on the functional and prognostic significance of its dynamic localization. Recent evidence shows that the direct interaction of survivin with the nuclear export receptor Crm1 is critically involved in its intracellular localization and cancer-relevant functions. Here, we review our current understanding of the Crm1/survivin interface and discuss its potential prognostic and therapeutic relevance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-5472eISSN: 1538-7445DOI: 10.1158/0008-5472.can-07-0494Titel-ID: cdi_proquest_miscellaneous_70700503
- Format
- –
- Schlagworte
- Active Transport, Cell Nucleus, Antineoplastic agents, Biological and medical sciences, Cell Nucleus - metabolism, Cytoplasm - metabolism, Exportin 1 Protein, Gene Expression Regulation, Neoplastic, Humans, Inhibitor of Apoptosis Proteins, Karyopherins - physiology, Medical sciences, Microtubule-Associated Proteins - biosynthesis, Mitosis, Models, Biological, Neoplasm Proteins - biosynthesis, Neoplasm Proteins - metabolism, Neoplasms - diagnosis, Neoplasms - metabolism, Neoplasms - pathology, Pharmacology. Drug treatments, Prognosis, Receptors, Cytoplasmic and Nuclear - physiology, Survivin, Tumors