Details

Autor(en) / Beteiligte

• Badger, S.A
• O'Donnell, M.E
• Boyd, C.S
• Hannon, R.J
• Lau, L.L
• Lee, B
• Soong, C.V

Titel

The Low Prevalence of Abdominal Aortic Aneurysm in Relatives in Northern Ireland

Ist Teil von

• European journal of vascular and endovascular surgery, 2007-08, Vol.34 (2), p.163-168

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2007

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Introduction Mortality from ruptured abdominal aortic aneurysm (AAA) remains high and has given impetus to screening. Targeted screening towards high-risk groups would increase efficacy. Relatives of previous AAA patients have been suggested as one such group. The aim of this study was therefore to determine the prevalence of AAA in relatives of previous patients in Northern Ireland. Patients and methods All living AAA patients, who underwent surgery between August 2001 and December 2005 in our unit, or were attending for follow-up of small aneurysms were contacted and asked for details of siblings and their family history. Screening by ultrasound was offered to the siblings and children over 50 years, with a defining threshold diameter for an aneurysm of 3.0 cm. Overall prevalence of AAA in the relatives was calculated. Separate prevalence rates were calculated according to relationship and gender of the patient and relative. Results 513 previous patients were contacted. 132 gave details of living relatives, resulting in a total of 405 relatives suitable for screening. 105 declined a scan, leaving 300 in the study. Overall mean age of the group was 63.0 ± 8.7 years and 68% were siblings of male patients. Overall ten AAAs were detected by screening, giving a prevalence of 3.3%. No aneurysms were found in the subgroup of children, while the highest prevalence (12.5%) was found in brothers of female patients. 20 additional AAAs were reported in these 132 families, resulting in 14 of the 132 families (10.6%) having two or more members with AAA. Conclusion The prevalence of screening detected AAA in this study is lower than anticipated. The reason is unclear, but demonstrates the multifactorial nature of the aetiology and genetic complexities yet to be unravelled by future research.