Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4154-4157
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Praziquantel derivatives I: Modification of the aromatic ring
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4154-4157
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2007.05.063Titel-ID: cdi_proquest_miscellaneous_70700011
- Format
- –
- Schlagworte
- Animals, Anthelmintic, Anthelmintics - chemistry, Anthelmintics - pharmacology, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antiparasitic agents, Biological and medical sciences, Drug Evaluation, Preclinical, Magnetic Resonance Spectroscopy, Medical sciences, Pharmacology. Drug treatments, Praziquantel, Praziquantel - analogs & derivatives, Praziquantel - pharmacology, Praziquantel derivatives, Schistosoma, Schistosoma mansoni - drug effects, Schistosomiasis