Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4284-4289
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and structure–activity relationship of imidazo(1,2- a)thieno(3,2- e)pyrazines as IKK-β inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (15), p.4284-4289
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The identification of a potent series of IKK-β selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog ( 22j) in the LPS-induced TNF-α release mouse model are described. The identification of a potent series of IKK-β selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog ( 22j) in the LPS-induced TNF-α release mouse model are described.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2007.05.031Titel-ID: cdi_proquest_miscellaneous_70699993
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Bones, joints and connective tissue. Antiinflammatory agents, Cells, Cultured, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Humans, I-kappa B Kinase - antagonists & inhibitors, IKK, Imidazothienopyrazine, Medical sciences, Mice, NF-κB, Pharmacology. Drug treatments, Pyrazines - chemical synthesis, Pyrazines - chemistry, Pyrazines - pharmacology, Structure-Activity Relationship, TNF-α