Details

Autor(en) / Beteiligte

• Wang, Jeff G., M.D
• Anderson, Richard A., Ph.D
• Graham, George M., M.D
• Chu, Micheline C., M.D
• Sauer, Mark V., M.D
• Guarnaccia, Michael M., M.D
• Lobo, Rogerio A., M.D

Titel

The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study

Ist Teil von

• Fertility and sterility, 2007-07, Vol.88 (1), p.240-243

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Cinnamon extract has been shown to reduce insulin resistance in in vitro and in vivo studies by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway and thus potentiating insulin action. Fifteen women with polycystic ovary syndrome (PCOS) were randomized to daily oral cinnamon and placebo for 8 weeks. Comparisons of post-treatment to baseline insulin sensitivity indices using fasting and 2-hour oral glucose tolerance tests showed significant reductions in insulin resistance in the cinnamon group but not in the placebo group. A larger trial is needed to confirm the findings of this pilot study and to evaluate the effect of cinnamon extract on menstrual cyclicity.