Details

Autor(en) / Beteiligte

• Buettcher, Michael
• Heininger, Ulrich
• Braun, Miles
• Bonhoeffer, Jan
• Halperin, Scott
• Heijbel, Harald
• de Menezes Martins, Reinaldo
• Vermeer-de Bondt, Patricia

Titel

Hypotonic-hyporesponsive episode (HHE) as an adverse event following immunization in early childhood: Case definition and guidelines for data collection, analysis, and presentation

Ist Teil von

• Vaccine, 2007-08, Vol.25 (31), p.5875-5881

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Preamble To increase comparability of vaccine clinical safety data and to improve the quality of reported data by applying the same criteria, the Hypotonic-hyporesponsive episode (HHE) Working Group has developed a case definition and guidelines for HHE applicable in study settings with different availability of resources, in health care settings that differ by availability of and access to health care, and in different geographic regions. Studies reporting on the follow-up of HHE relying on parental reporting and neurodevelopmental testing demonstrated HHE to be a self-limiting event without long-term sequelae [3,9,16,20]. [...]the pathogenesis of HHE is unknown and has been poorly studied given the constraints of investigating a condition that is rare and results in transient signs.