Details

Autor(en) / Beteiligte

• Mitova, Maya I
• Lang, Gerhard
• Blunt, John W
• Cummings, Nicholas J
• Cole, Anthony L. J
• Robinson, Ward T
• Munro, Murray H. G

Titel

Cladobotric Acids A−F:  New Cytotoxic Polyketides from a New Zealand Cladobotryum sp

Ist Teil von

• Journal of organic chemistry, 2006-01, Vol.71 (2), p.492-497

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cladobotric acids A−F (1−6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1−6 was concluded from feeding experiments with 13C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A−F (1−6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.