Details

Autor(en) / Beteiligte

• Donaldson, Scott H
• Bennett, William D
• Zeman, Kirby L
• Knowles, Michael R
• Tarran, Robert
• Boucher, Richard C

Titel

Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline

Ist Teil von

• The New England journal of medicine, 2006-01, Vol.354 (3), p.241-250

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2006

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Inhalation of hypertonic saline has a modest beneficial effect on lung function and the frequency of exacerbations in patients with cystic fibrosis. In this article, the investigators provide in vivo and in vitro data suggesting that this therapeutic effect derives from sustained acceleration of mucus clearance. The investigators provide in vivo and in vitro data suggesting that the therapeutic effect of inhaled hypertonic saline derives from sustained acceleration of mucus clearance. Mucus clearance defends the lung against inhaled bacteria. The efficiency of mucus clearance depends on an adequate volume of airway surface liquid (i.e., hydration). 1 One hypothesis for the pathogenesis of lung disease in patients with cystic fibrosis is that a lack of regulation of sodium absorption and chloride secretion causes depletion of airway surface liquid, slows mucus clearance, and promotes the formation of adherent mucus plaques on airway surfaces. Mucus plaques and plugs obstruct airways and provide the nidus for infection. 2 , 3 On the basis of this hypothesis, therapies that increase the volume of airway surface liquid, and hence mucus . . .