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Cytological aspects of melanotic variant of medullary thyroid carcinoma
Diagnostic cytopathology, 2001-03, Vol.24 (3), p.206-208
de Lima, Marcus Aurelho
Dias Medeiros, Juliana
Rodrigues da Cunha, Liane
de Cássia Caldas Pessôa, Rita
Silveira Tavares, Fernanda
de Fátima Borges, Maria
Marinho, Eurípedes Oliveira
2001
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
de Lima, Marcus Aurelho
Dias Medeiros, Juliana
Rodrigues da Cunha, Liane
de Cássia Caldas Pessôa, Rita
Silveira Tavares, Fernanda
de Fátima Borges, Maria
Marinho, Eurípedes Oliveira
Titel
Cytological aspects of melanotic variant of medullary thyroid carcinoma
Ist Teil von
Diagnostic cytopathology, 2001-03, Vol.24 (3), p.206-208
Ort / Verlag
New York: John Wiley & Sons, Inc
Erscheinungsjahr
2001
Quelle
Wiley Online Library Core Title
Beschreibungen/Notizen
We had the opportunity to examine a case of fine‐needle aspiration (FNA) of a melanotic variant of medullary thyroid carcinoma (MTC) in a 20‐yr‐old man. The patient presented a single node, hardened and mobile upon deglutition, in the right lobe of the thyroid, for 9 mo, without symptoms of glandular dysfunction. Calcitonin (138 pg/ml), urinary calcium (177 mg/dl), and the carcinoembryonic antigen (341 ng/ml) were increased. The nodular aspirate, drawn by FNA, was represented by pleomorphic cells, with frequent intranuclear cytoplasmic inclusions, sometimes bi‐ or multinucleated, with abundant, finely granular cytoplasm, sometimes containing a brown pigment resembling melanin. An immunohistochemical study using monoclonal antibodies (Dako Corp., Carpinteria, CA) showed that the neoplastic cells were intensely and diffusely positive for calcitonin and chromogranin, and focally positive for HMB45. In view of these findings, the case was characterized as a melanotic variant of medullary carcinoma, a rare type of neoplasia, but having a prognosis similar to the classical variant of MTC. Diagn. Cytopathol. 2001;24:206–208. © 2001 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-1039
eISSN: 1097-0339
DOI: 10.1002/1097-0339(200103)24:3<206::AID-DC1042>3.0.CO;2-H
Titel-ID: cdi_proquest_miscellaneous_70669304
Format
–
Schlagworte
Adult
,
Antigens, Neoplasm
,
Biological and medical sciences
,
Carcinoma, Medullary - diagnosis
,
Carcinoma, Medullary - pathology
,
Carcinoma, Medullary - surgery
,
Diagnosis, Differential
,
Endocrinopathies
,
fine-needle aspiration
,
Humans
,
immunohistochemistry
,
Male
,
Malignant tumors
,
Medical sciences
,
medullary carcinoma
,
melanin
,
Melanins - analysis
,
Melanocytes - pathology
,
Melanoma - diagnosis
,
Melanoma - pathology
,
Melanoma-Specific Antigens
,
Neoplasm Proteins - analysis
,
thyroid
,
Thyroid Neoplasms - diagnosis
,
Thyroid Neoplasms - pathology
,
Thyroid Neoplasms - surgery
,
Thyroid. Thyroid axis (diseases)
,
Thyroidectomy
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