Details

Autor(en) / Beteiligte

• Christensen, Adam P
• Corey, David P

Titel

TRP channels in mechanosensation: direct or indirect activation?

Ist Teil von

• Nature reviews. Neuroscience, 2007-07, Vol.8 (7), p.510-521

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2007

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• Ion channels of the transient receptor potential (TRP) superfamily are involved in a wide variety of neural signalling processes, most prominently in sensory receptor cells. They are essential for mechanosensation in systems ranging from fruitfly hearing, to nematode touch, to mouse mechanical pain. However, it is unclear in many instances whether a TRP channel directly transduces the mechanical stimulus or is part of a downstream signalling pathway. Here, we propose criteria for establishing direct mechanical activation of ion channels and review these criteria in a number of mechanosensory systems in which TRP channels are involved.