UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 16 von 29
Datensatz exportieren als...
BibTeX
Design and synthesis of cationic Aib-containing antimicrobial peptides: conformational and biological studies
Journal of peptide science, 2007-07, Vol.13 (7), p.481-486
Zikou, Sofia
Koukkou, Anna-Irini
Mastora, Panorea
Sakarellos-Daitsiotis, Maria
Sakarellos, Constantinos
Drainas, Constantin
Panou-Pomonis, Eygenia
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Zikou, Sofia
Koukkou, Anna-Irini
Mastora, Panorea
Sakarellos-Daitsiotis, Maria
Sakarellos, Constantinos
Drainas, Constantin
Panou-Pomonis, Eygenia
Titel
Design and synthesis of cationic Aib-containing antimicrobial peptides: conformational and biological studies
Ist Teil von
Journal of peptide science, 2007-07, Vol.13 (7), p.481-486
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2007
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Development of antimicrobial peptides has attracted considerable attention in recent years due to the excessive use of antibiotics, which has led to multiresistant bacteria. Cationic amphiphilic Aib‐containing peptide models Ac‐(Aib‐Arg‐Aib‐Leu)n‐NH2, n = 1–4, and sequential cationic polypeptides (Arg‐X‐Gly)n, X = Ala, Val, Leu, were prepared and studied for their antimicrobial and hemolytic activity, as well as for their proteolytic stability. Ac‐(Aib‐Arg‐Aib‐Leu)n‐NH2, n = 2, 3 and the polypeptide (Arg‐Leu‐Gly)n exhibited significant antimicrobial activity, and they were nontoxic at their MIC values and resistant, in particular the Aib‐peptide models, to enzymatic degradation. The conformational characteristics of the peptide models were studied by circular dichroism (CD). Structure‐activity relationship studies revealed the importance of the amphipathic α‐helical conformation of the reported peptides in inducing antimicrobial effects. It is concluded that peptide models comprising cationic amino acids (Arg), helicogenic and noncoding residues (Aib) and/or hydrophobic and helix‐promoting components (Leu) may lead to the development of antimicrobial therapeutics. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1075-2617
eISSN: 1099-1387
DOI: 10.1002/psc.876
Titel-ID: cdi_proquest_miscellaneous_70651634
Format
–
Schlagworte
Amino Acid Sequence
,
Aminoisobutyric Acids - chemistry
,
Anti-Infective Agents - chemical synthesis
,
Anti-Infective Agents - chemistry
,
Anti-Infective Agents - pharmacology
,
antimicrobial activity
,
Bacteria - drug effects
,
cationic Aib-containing peptides
,
Circular Dichroism
,
Drug Design
,
Hemolysis - drug effects
,
hemolytic assay
,
Humans
,
Oligopeptides - chemical synthesis
,
Oligopeptides - chemistry
,
Oligopeptides - pharmacology
,
Protein Conformation
,
proteolytic stability
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX