European journal of pharmacology, 2001-02, Vol.413 (2), p.179-187
2001
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Details
- Autor(en) / Beteiligte
- Titel
- Characterisation of the prejunctional inhibitory muscarinic receptor on cholinergic nerves in the rat urinary bladder
- Ist Teil von
- European journal of pharmacology, 2001-02, Vol.413 (2), p.179-187
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 2001
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The nature of the prejunctional inhibitory muscarinic receptor on cholinergic nerve endings in the rat urinary bladder was investigated by measuring stimulated endogenous acetylcholine release via high pressure liquid chromatography (HPLC), in the presence of various selective muscarinic antagonists. The rank order of potencies for the antagonists used was: atropine (−log concentration=7.8)>4-DAMP (4-diphenylacetoxy- N-methylpiperidine) (7.6)>tripitramine (7.3)=HHD (hexahydrodifenidol) (7.3)>pFHHSiD ( p-fluoro-hexahydrosiladifenidol hydrochloride) (7.0)>himbacine (6.5)>methoctramine (5.9)≥pirenzepine (5.8)>gallamine (4.3). A comparison of the antagonist potencies obtained, with affinity constants at muscarinic M 1 to M 5 receptors, suggests that the prejunctional inhibitory muscarinic receptor is of the M 4 receptor subtype.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2999eISSN: 1879-0712DOI: 10.1016/S0014-2999(01)00746-4Titel-ID: cdi_proquest_miscellaneous_70648742
- Format
- –
- Schlagworte
- Acetylcholine - metabolism, Animals, Biological and medical sciences, Cell receptors, Cell structures and functions, Cholinergic Fibers - drug effects, Cholinergic Fibers - metabolism, Cholinergic nerve, Chromatography, High Pressure Liquid, Electric Stimulation, Female, Fundamental and applied biological sciences. Psychology, Male, Molecular and cellular biology, Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine), Muscarinic Antagonists - pharmacology, Muscarinic receptor, Pirenzepine - pharmacology, prejunctional, rat, Rats, Rats, Wistar, Receptor, Muscarinic M4, Receptors, Muscarinic - drug effects, Receptors, Muscarinic - metabolism, Urinary bladder, Urinary Bladder - drug effects, Urinary Bladder - metabolism, Vertebrates: urinary system