Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3997-4000
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3997-4000
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a carrageenan-induced rat hyperalgesia model of pain. A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a carrageenan-induced rat hyperalgesia model of pain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2007.04.084Titel-ID: cdi_proquest_miscellaneous_70647656
- Format
- –
- Schlagworte
- Administration, Oral, Analgesics, Animals, Benzamidines - administration & dosage, Benzamidines - pharmacology, Benzamidines - therapeutic use, Biological and medical sciences, Cyclic benzamidines, Excitatory Amino Acid Antagonists - administration & dosage, Excitatory Amino Acid Antagonists - pharmacology, Glutamatergic system (aspartate and other excitatory aminoacids), Medical sciences, Models, Biological, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, NR2B-selective NMDA, Pain - drug therapy, Pharmacology. Drug treatments, Rats, Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors