Details

Autor(en) / Beteiligte

• Monteith, Gregory R
• McAndrew, Damara
• Faddy, Helen M
• Roberts-Thomson, Sarah J

Titel

Calcium and cancer: targeting Ca2+ transport

Ist Teil von

• Nature reviews. Cancer, 2007-07, Vol.7 (7), p.519-530

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?