Details

Autor(en) / Beteiligte

• Romagnani, Sergio, MD

Titel

Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis

Ist Teil von

• Journal of allergy and clinical immunology, 2007-06, Vol.119 (6), p.1511-1513

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2007

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The initial interpretations, based on several in vitro and in vivo models, concluded that a lack of shifting of allergen-specific responses from the TH2 to the TH1 phenotype (ie, a missing immune deviation) because of the reduced microbial burden in the early childhood was accountable.1-3 It was indeed widely shown that cytokines such as IL-12, IL-18, IFN-γ, and IFN-α polarize the allergen-specific TH response toward the TH1 profile both in vitro and in vivo. [...]many pathogen-associated molecular patterns, such as LPS, double-stranded RNA, and CpG-containing oligodeoxynucleotides, exhibit the same effect by interacting with Toll-like receptors (TLRs) expressed by dendritic cells (DCs) and by other cells of the innate immunity.