Details

Autor(en) / Beteiligte

• HEDIN, Henrietta L. M
• ERIKSSON, Sture
• FOWLER, Christopher J

Titel

Human platelet calcium mobilisation in response to β-amyloid (25-35) : buffer dependency and unchanged response in Alzheimer's disease

Ist Teil von

• Neurochemistry international, 2001-02, Vol.38 (2), p.145-151

Ort / Verlag

Oxford: Elsevier

Erscheinungsjahr

2001

Link zum Volltext

Quelle

EZB-NALI5-00465 Elsevier Archive NL

Beschreibungen/Notizen

• In the present study, the effects of beta-amyloid (25-35) (Abeta (25-35)) upon calcium signalling by the human platelet has been investigated. When assays were conducted using HEPES buffers, Abeta (25-35), but not the inactive peptide Abeta (35-25), produced a robust increase in intracellular calcium that remained after removal of extracellular calcium but was abolished by the phospholipase C inhibitor U-73122. There was no significant difference between the calcium response to Abeta (25-35) in platelets from patients with Alzheimer's disease and from age-matched controls. In contrast to the robust effects on calcium mobilisation in HEPES buffers, very little calcium response to Abeta (25-35) was seen when Krebs (pH 7.8) buffer was used.