Details

Autor(en) / Beteiligte

• Haagsma, Elizabeth B
• Hagens, Vincent E
• Schaapveld, Michael
• van den Berg, Aad P
• de Vries, Elisabeth G.E
• Klompmaker, Ids J
• Slooff, Maarten J.H
• Jansen, Peter L.M

Titel

Increased cancer risk after liver transplantation: a population-based study

Ist Teil von

• Journal of hepatology, 2001, Vol.34 (1), p.84-91

Ort / Verlag

Oxford: Elsevier B.V

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Background/Aims : Development of de novo malignancies emerges as a serious long term complication after liver transplantation. Methods : We reviewed the medical records of 174 adult one-year survivors for de novo malignancies. The observed cancer rates were compared with the expected cancer rates in the Dutch population. Results : Twenty-one of the 174 patients developed 23 malignancies (12%). Skin and lip cancer accounted for 12 of the 23 malignancies (52%). Only one patient had a B-cell lymphoma. The cumulative risk for de novo malignancy was 6, 20, and 55% at 5, 10, and 15 years after transplantation, respectively. The overall relative risk (RR) as compared with the general population was 4.3 (95% confidence interval 2.4–7.1). Significantly increased RRs were observed for non-melanoma skin cancer (RR 70.0), non-skin solid cancer (RR 2.7), renal cell cancer (RR 30.0), and colon cancer (RR 12.5). Multivariate analysis showed that an age>40 years and pretransplant use of immunosuppression were significant risk factors. Conclusions : An increased risk of cancer exists after liver transplantation, for both for skin/lip cancer, and other solid tumors. Older age and the use of immunosuppression are risk factors.