Details

Autor(en) / Beteiligte

• Zhang, Yan-Jin
• Davis, Thomas L.
• Wang, Xin-Ping
• Deng, Jian-Hong
• Baillargeon, Jacques
• Yeh, I-Tien
• Jenson, Hal B.
• Gao, Shou-Jiang

Titel

Distinct Distribution of Rare US Genotypes of Kaposi's Sarcoma—Associated Herpesvirus (KSHV) in South Texas: Implications for KSHV Epidemiology

Ist Teil von

• The Journal of infectious diseases, 2001-01, Vol.183 (1), p.125-129

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2001

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Genotypes of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF)-K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75% exhibited C subtype and 25% exhibited A subtype. K15 genotyping showed that 56% exhibited M form, of which 89% exhibited C3 K1 subtype and 44% exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78% were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50%) than in other US regions (3%) and that M form KSHV likely existed in this region long before the AIDS epidemic.