Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3330-3334
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and antibacterial activity of derivatives of 6- O-allylic acylides
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3330-3334
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A facile way to assemble a series of potent acylide derivatives against both macrolide-susceptible and macrolide-resistant strains was reported. A series of novel acylide derivatives have been synthesized from erythromycin A via a facile procedure. By applying this procedure, cyclic carbonation to C-11,12 position, acylation to C-3 hydroxyl, and deprotection provided the desired acylides. These compounds showed antibacterial activity against both macrolide-susceptible strains and macrolide-resistant strains. Because of existence of 6- O-allyl substitution, these derivatives can be used as intermediates for further structural modification.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2007.03.107Titel-ID: cdi_proquest_miscellaneous_70568790
- Format
- –
- Schlagworte
- Acylation, Acylide, Alkenes - chemical synthesis, Alkenes - pharmacology, Allylic, Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - pharmacology, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Biological and medical sciences, Drug Resistance, Multiple, Bacterial, Erythromycin - analogs & derivatives, Erythromycin - chemical synthesis, Erythromycin - pharmacology, Gram-Negative Bacteria - drug effects, Gram-Positive Bacteria - drug effects, Macrolide, Macrolides - chemical synthesis, Macrolides - pharmacology, Medical sciences, Microbial Sensitivity Tests, Models, Chemical, Pharmacology. Drug treatments, Resistant bacteria, Structure-Activity Relationship