Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice
2007
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- Autor(en) / Beteiligte
- Titel
- Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice
- Ist Teil von
- International Journal of Obesity, 2007-06, Vol.31 (6), p.1023-1029
- Ort / Verlag
- Basingstoke: Nature Publishing
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Objective: To investigate the anti-obesity effects of the pomegranate leaf extract (PLE) in a mouse model of high-fat diet induced obesity and hyperlipidemia. Design: For the anti-obesity experiment, male and female ICR mice were fed with a high-fat diet to induce obesity. When the weight of the high-fat diet group was 20% higher than the normal diet group, the animals were treated with 400 or 800 mg/kg/day of PLE for 5 weeks. Body weight and daily food intake were measured regularly during the experimental period. The various adipose pads were weighed and serum total cholesterol (TC), triglyceride (TG), glucose and high-density lipoprotein cholesterol (HDL-C) were measured after 5 weeks, treatment with PLE. In the fat absorption experiment, both the normal and obese mice were given 0.5 ml lipid emulsion and PLE at a dose of 800 mg/kg at the same time. Serial serum TG levels were measured at times 1, 2, 3, 4 and 6 h after the treatment. TGs in fecal excretions were measured after the mice were orally given a lipid emulsion. Effects of PLE and its isolated compounds (ellagic acid and tannic acid) on pancreatic lipase activity were examined in vitro. Results: The PLE-treated groups showed a significant decrease in body weight, energy intake and various adipose pad weight percents and serum, TC, TG, glucose levels and TC/HDL-C ratio after 5 weeks treatment. Furthermore, PLE significantly attenuated the raising of the serum TG level and inhibited the intestinal fat absorption in mice given a fat emulsion orally. PLE showed a significant difference in decreasing the appetite of obese mice fed a high-fat diet, but showed no effect in mice fed a normal diet. Conclusion: PLE can inhibit the development of obesity and hyperlipidemia in high-fat diet induced obese mice. The effects appear to be partly mediated by inhibiting the pancreatic lipase activity and suppressing energy intake. PLE may be a novel appetite suppressant that only affects obesity owing to a high-fat diet.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0307-0565eISSN: 1476-5497DOI: 10.1038/sj.ijo.0803502Titel-ID: cdi_proquest_miscellaneous_70560438
- Format
- –
- Schlagworte
- Absorption, Acids, animal models, Animals, antiobesity properties, Appetite, Appetite - drug effects, Biological and medical sciences, blood glucose, blood lipids, body fat, Body weight, Cardiovascular disease, cholesteremic effect, Cholesterol, Control, Diet, dietary fat, Dietary Fats - administration & dosage, Dietary Fats - pharmacokinetics, dietary supplements, Disease Models, Animal, dosage, Emulsions, Emulsions - administration & dosage, energy balance, energy intake, Experiments, feces, Feeding. Feeding behavior, Female, Females, food intake, fruit crops, Fundamental and applied biological sciences. Psychology, Glucose, High density lipoprotein, high fat diet, Hyperlipidemia, Hyperlipidemias - complications, Hyperlipidemias - drug therapy, Intestines - metabolism, Laboratory animals, leaves, Lipase - metabolism, Lipids, Male, Materia medica, Vegetable, Medical sciences, Metabolic diseases, Mice, Mice, Inbred ICR, Obesity, Obesity - complications, Obesity - drug therapy, Pancreas - enzymology, Pharmaceutical sciences, Physiological aspects, Phytotherapy - methods, Plant extracts, Plant Extracts - therapeutic use, Plant Leaves, Pomegranate, pomegranates, Punica granatum, Punicaceae, Tannic acid, triacylglycerol lipase, triacylglycerols, Triglycerides - blood, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Weight control