Seminars in immunology, 2007-06, Vol.19 (3), p.162-172
2007
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Details
- Autor(en) / Beteiligte
- Titel
- mTOR at the crossroads of T cell proliferation and tolerance
- Ist Teil von
- Seminars in immunology, 2007-06, Vol.19 (3), p.162-172
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Several events control the activation, proliferation, and the continued Ag responsiveness of naïve and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1044-5323eISSN: 1096-3618DOI: 10.1016/j.smim.2007.02.008Titel-ID: cdi_proquest_miscellaneous_70544483
- Format
- –
- Schlagworte
- Allergy and Immunology, Anergy, Animals, CD4+ T cells, Cell Proliferation, Clonal Anergy - immunology, Humans, Immune Tolerance - immunology, Lymphocyte Activation - physiology, mTOR, Proliferation, Protein Kinases - physiology, Signal Transduction - immunology, T-Lymphocytes - cytology, T-Lymphocytes - immunology, TOR Serine-Threonine Kinases