Details

Autor(en) / Beteiligte

• Tong, J
• Boyko, E. J
• Utzschneider, K. M
• McNeely, M. J
• Hayashi, T
• Carr, D. B
• Wallace, T. M
• Zraika, S
• Gerchman, F
• Leonetti, D. L
• Fujimoto, W. Y
• Kahn, S. E

Titel

Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans

Ist Teil von

• Diabetologia, 2007-06, Vol.50 (6), p.1156-1160

Ort / Verlag

Berlin: Berlin/Heidelberg : Springer-Verlag

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Aims/hypothesis Intra-abdominal fat (IAF) is an important risk factor for CHD and type 2 diabetes, and in cross-sectional studies is associated with the metabolic syndrome (MetS). Our aim was to determine whether IAF accumulation predicts the future development of MetS in non-diabetic Japanese-Americans. Subjects and methods We conducted a prospective study of 457 Japanese-American men and women (mean±SD: age 51.5 ± 12.0 years, BMI 23.9 ± 3.1 kg/m²) without diabetes or MetS at baseline. Of these, 408 completed a 5-year follow-up and 366 completed a 10-year follow-up. BMI, waist circumference, IAF and subcutaneous fat (SCF) areas by computed tomography, blood pressure, fasting plasma glucose, insulin, triacylglycerol and HDL-cholesterol were measured at baseline and at 5- and 10-year follow-up. MetS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria. Results Incidence of MetS was 15.3% at 5 years and 17.8% at 10 years. A change of 1 SD in IAF area was associated with a 2.1-fold increase in the odds of MetS at 10 years (odds ratio = 2.08, 95% CI 1.41-3.07) after adjusting for age, sex, baseline IAF and the presence of each individual MetS criteria at baseline. This association was independent of changes in fasting insulin and SCF areas. Conclusions/interpretation We conclude that IAF accumulation over time independently predicts the development of MetS and thus may play an important role in the development of MetS in Japanese-Americans.