Details

Autor(en) / Beteiligte

• Florea, Anca V
• Ionescu, Diana N
• Melhem, Mona F

Titel

Parvovirus B19 infection in the immunocompromised host

Ist Teil von

• Archives of pathology & laboratory medicine (1976), 2007-05, Vol.131 (5), p.799-804

Ort / Verlag

United States: College of American Pathologists

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Human parvovirus B19 is a single-stranded DNA virus with a predilection for infecting rapidly dividing cell lines, such as bone marrow erythroid progenitor cells. People with defective cell-mediated immunity (eg, severe combined immunodeficiency syndrome; acquired immunodeficiency syndrome; and patients receiving immunosuppressive therapy, ie, post organ transplant) can develop pure red cell aplasia, in which suppression of erythroid precursors is permanent. Identification of parvovirus inclusions in marrow biopsies and subsequent confirmation of infection by in situ hybridization is important in the assessment of anemia in immunodeficient patients. Our objective is to provide a general overview of the parvovirus B19 infection and its characteristics in immunocompromised patients and to summarize updated information regarding the clinicopathologic features, pathobiology, and laboratory diagnosis of this subject. The pathologist should be aware of the wide spectrum of manifestations of parvovirus B19 infection depending on the patient's hematologic and immunologic status.