FEBS letters, 2007-05, Vol.581 (10), p.2041-2046
2007
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- Autor(en) / Beteiligte
- Titel
- Load application induces changes in the expression levels of Sox-9, FGFR-3 and VEGF in condylar chondrocytes
- Ist Teil von
- FEBS letters, 2007-05, Vol.581 (10), p.2041-2046
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2007
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Experimental and clinical observations have proven the modulatory effects of mechanical loading on the development and maintenance of cartilage architecture. Here we examined the involvement of Sox-9, FGFR-3 and VEGF (pivotal factors controlling cartilage development and growth) in the mechano-transduction pathway of mandibular condylar cartilage by changing the dynamics of the transmitted load via changes in food hardness. To this end, condyle cartilage tissue of rats fed with hard or soft food was analyzed immunohistochemically at various time points. Our findings demonstrate that different mechanical loading conditions in condylar chondrocytes trigger differentiation-/maturation-related processes by affecting the expression levels of these factors, ultimately influencing condylar cartilage growth.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2007.04.037Titel-ID: cdi_proquest_miscellaneous_70465806
- Format
- –
- Schlagworte
- activator protein-1, Animals, AP-1, Cartilage tissue, Cell Proliferation, Chondrocytes - cytology, Chondrocytes - metabolism, Condylar chondrocytes, Female, FGF, FGF receptor 3, FGFR-3, fibroblast growth factor, High Mobility Group Proteins - metabolism, Hypertrophy, Mandibular Condyle - cytology, Mandibular Condyle - physiology, Mechanical load, Rats, Rats, Wistar, Receptor, Fibroblast Growth Factor, Type 3 - metabolism, runt-related transcription factor 2, Runx2, Sox-9, SOX9 Transcription Factor, TBS, Transcription Factors - metabolism, Tris-buffered saline, Vascular endothelial growth factor, Vascular Endothelial Growth Factor A - metabolism, VEGF, Weight-Bearing