Details

Autor(en) / Beteiligte

• TISEO, Marcello
• ARDIZZONI, Andrea
• ARGENIDE CAFFERATA, Mara
• LOPREVITE, Maura
• CHIARAMONDIA, Maurizio
• FILIBERTI, Rosangela
• MARRONI, Paola
• GROSSI, Francesco
• PAGANUZZI, Michela

Titel

Predictive and Prognostic Significance of Neuron-specific Enolase (NSE) in Non-small Cell Lung Cancer

Ist Teil von

• Anticancer research, 2008-01, Vol.28 (1B), p.507-513

Ort / Verlag

Attiki: International Institute of Anticancer Research

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: The predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. Patients and Methods: To study these aspects, serum NSE was prospectively measured at baseline of first-line chemotherapy treatment and tested for correlation with clinical outcome in 129 advanced NSCLC patients. Results: An objective response was achieved in 27 out of 65 (41.5%) patients with NSE <8.6 ng/ml and in 38 out of 64 (59.4%) patients with NSE ≥8.6 ng/ml (p=0.05). Logistic analysis confirmed the positive association between objective response and NSE values ≥8.6 ng/ml (odds ratio=1.69; 95% confidence interval: 1.09-2.63; p=0.02). Overall median survival was 10.8 months. A statistically significant prognostic effect on survival was found for performance status, stage and response to treatment, but not for baseline NSE value. Conclusion: Based on these data, baseline circulating tumor NSE levels appear to have a weak predictive role, but not a prognostic significance in patients with advanced NSCLC submitted to standard chemotherapy.