Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2718-2722
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2718-2722
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We have previously reported a novel class of tetrahydroindazoles that display potency against a variety of Gram-positive and Gram-negative bacteria, potentially via interaction with type II bacterial topoisomerases. Herein are reported SAR investigations of this new series. Several compounds possessing broad-spectrum potency were prepared. Further, these compounds exhibit activity against multidrug-resistant Gram-positive microorganisms equivalent to that against susceptible strains.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2007.03.004Titel-ID: cdi_proquest_miscellaneous_70446813
- Format
- –
- Schlagworte
- Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Bacteria, Bacterial resistance, Biological and medical sciences, Broad-spectrum, Drug Design, Drug Resistance, Multiple - physiology, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Escherichia coli, Gyrase, Indazoles - pharmacology, Medical sciences, MIC, Microbial Sensitivity Tests, Pharmacology. Drug treatments, Quinolone, SAR, Staphylococcus aureus, Streptococcus pneumoniae, Structure-Activity Relationship, Tetrahydroindazole, Topoisomerase, Topoisomerase II Inhibitors