Angewandte Chemie (International ed.), 2008-03, Vol.47 (15), p.2804-2807
2008
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- Autor(en) / Beteiligte
- Titel
- A Near-Infrared-Fluorescence-Quenched Gold-Nanoparticle Imaging Probe for In Vivo Drug Screening and Protease Activity Determination
- Ist Teil von
- Angewandte Chemie (International ed.), 2008-03, Vol.47 (15), p.2804-2807
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nanodiagnosis: A matrix‐metalloproteinase (MMP) sensitive gold‐nanoparticle (AuNP) imaging probe quenches conjugated near‐infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro and in vivo. Experiments disclose an apparent positive contrast in MMPs‐positive tumor‐bearing mice (right).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.200705240Titel-ID: cdi_proquest_miscellaneous_70435378
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - analysis, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, cancer diagnosis, Cell Line, Tumor, drug screening, Drug Screening Assays, Antitumor - instrumentation, Drug Screening Assays, Antitumor - methods, fluorescent probes, gold, Gold - chemistry, Humans, imaging agents, Metal Nanoparticles - chemistry, Metal Nanoparticles - ultrastructure, Mice, Mice, Nude, Microscopy, Electron, Transmission, Peptide Hydrolases - analysis, Peptide Hydrolases - metabolism, Protease Inhibitors - analysis, Protease Inhibitors - chemistry, Protease Inhibitors - pharmacology, Spectrometry, Fluorescence, Spectrophotometry, Infrared