Details

Autor(en) / Beteiligte

• Takatori, H
• Natsugoe, S
• Okumura, H
• Matsumoto, M
• Uchikado, Y
• Setoyama, T
• Sasaki, K
• Tamotsu, K
• Owaki, T
• Ishigami, S
• Aikou, T

Titel

Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma

Ist Teil von

• European journal of surgical oncology, 2008-04, Vol.34 (4), p.397-402

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Aim Esophageal carcinoma is one of the most aggressive malignancies. Many studies have examined various biological factors associated with the malignant potential of esophageal carcinoma. Cyclooxygenase (COX)-2 is overexpressed in various types of human malignancies, including esophageal carcinomas. Although some groups have described COX-2 expression in esophageal adenocarcinoma, few studies have reported COX-2 expression in esophageal squamous cell carcinoma (ESCC). Methods We immunohistochemically investigated relationships between COX-2 overexpression in surgical specimens of primary tumors in 228 patients with ESCC. Relationships between COX-2 expression and clinicopathological factors, including prognosis, were analyzed. COX-2 expressions were classified into 4 criteria: Score 0, no staining; Score 1, <10% staining; Score 2, 10–90% staining; and Score 3, >90% staining. Results Scores of COX-2 immunoreactivity in 228 patients were as follows: Score 0, 21 of 228; Score 1, 71of 228; Score 2, 117 of 228; and Score 3, 19 of 228, respectively. COX-2 expression was significantly correlated with depth of invasion and tumor stage ( p = 0.03 and p = 0.04, respectively). The 5-year survival rate of patients decreased significantly with increased expression of COX-2 ( p = 0.005). Multivariate regression analysis indicated COX-2 expression as an independent prognostic factor for ESCC. Conclusions COX-2 overexpression was significantly correlated with depth of invasion, tumor stage and survival in ESCC. Evaluation of COX-2 expression should be useful for determining tumor properties, including prognosis, in patients with ESCC.