Cerebral cortex (New York, N.Y. 1991), 2008-04, Vol.18 (4), p.938-950
2008
Details
- Autor(en) / Beteiligte
- Titel
- Absence of LPA1 Signaling Results in Defective Cortical Development
- Ist Teil von
- Cerebral cortex (New York, N.Y. 1991), 2008-04, Vol.18 (4), p.938-950
- Ort / Verlag
- United States: Oxford University Press
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein–coupled receptors. At least 2 LPA receptors, LPA1 and LPA2, are expressed in the developing brain, the former enriched in the neurogenic ventricular zone (VZ), suggesting a normal role in neurogenesis. Despite numerous studies reporting the effects of exogenous LPA using in vitro neural models, the first LPA1 loss-of-function mutants reported did not show gross cerebral cortical defects in the 50% that survived perinatal demise. Here, we report a role for LPA1 in cortical neural precursors resulting from analysis of a variant of a previously characterized LPA1-null mutant that arose spontaneously during colony expansion. These LPA1-null mice, termed maLPA1, exhibit almost complete perinatal viability and show a reduced VZ, altered neuronal markers, and increased cortical cell death that results in a loss of cortical layer cellularity in adults. These data support LPA1 function in normal cortical development and suggest that the presence of genetic modifiers of LPA1 influences cerebral cortical development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1047-3211eISSN: 1460-2199DOI: 10.1093/cercor/bhm132Titel-ID: cdi_proquest_miscellaneous_70389736
- Format
- –
- Schlagworte
- Animals, Animals, Newborn, Apoptosis, brain development, Cell Division, Cell Movement, Cells, Cultured, cerebral cortex, Cerebral Cortex - abnormalities, Cerebral Cortex - cytology, Cerebral Cortex - physiology, Female, Gene Expression Regulation, Developmental, LPA, lysophosphatidic acid, Lysophospholipids - metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, neurogenesis, Pregnancy, Receptors, Lysophosphatidic Acid - genetics, Receptors, Lysophosphatidic Acid - metabolism, Signal Transduction - physiology, Stem Cells - cytology