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PERITONEAL DIALYSIS IN THE COMPREHENSIVE MANAGEMENT OF END-STAGE RENAL DISEASE PATIENTS WITH LIVER CIRRHOSIS AND ASCITES: PRACTICAL ASPECTS AND REVIEW OF THE LITERATURE
REDinREN (Spanish Renal Research Network) and Hospital Universitario La
Paz, Madrid, Spain
Correspondence to: R. Selgas, Servicio de Nefrología, Hospital
Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain.
rselgas.hulp{at}salud.madrid.org
The treatment of cirrhotic patients with ascites and end-stage renal
disease is complex, due mainly to decreased effective arterial volume and
hemodynamic instability. Peritoneal dialysis as a continuous therapy
represents an alternative to hemodialysis-related intolerance. We report on
our experience and that of others with cirrhotic patients with ascites treated
by peritoneal dialysis. Hemodynamic tolerance was excellent in all patients
and solute and water peritoneal transport increased to above the normal range
in almost all cases. Morbidity and mortality were related principally to liver
disease and other comorbidities. Peritoneal protein losses, initially high,
decreased over time, maintaining serum albumin within the low normal range.
The incidence of peritonitis was similar or slightly higher than usual in
these patients, with peculiar etiology. The experiences with peritoneal
dialysis suggest consideration of this treatment as the first choice for
cirrhotic patients with ascites and that need to start dialysis.
KEY WORDS: Ascites; liver cirrhosis; end-stage renal disease.
Received 11 November 2007;
accepted 14 January 2008.