Angewandte Chemie International Edition, 2007-01, Vol.46 (16), p.2839-2843
2007
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Details
- Autor(en) / Beteiligte
- Titel
- O-Glycoside Orientation Is an Essential Aspect of Base J Recognition by the Kinetoplastid DNA-Binding Protein JBP1
- Ist Teil von
- Angewandte Chemie International Edition, 2007-01, Vol.46 (16), p.2839-2843
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A binding edge? Comparison of dissociation constants and molecular‐dynamics snapshots of a panel of synthetic telomeric double‐stranded DNA sequences containing HMdU O‐glycosides has revealed that the DNA‐binding protein of kinetoplastids, such as Leishmania and Trypanosoma, JBP1, recognizes a critical edge‐on conformation of the pyranosyl ring of base J. If this conformation is perturbed, JBP1 binding is dramatically reduced.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.200604635Titel-ID: cdi_proquest_miscellaneous_70366162
- Format
- –
- Schlagworte
- Animals, DNA, DNA - chemistry, DNA, Protozoan - chemistry, DNA, Recombinant - chemistry, DNA-Binding Proteins - chemistry, Fluorescence Polarization, glycosides, Glycosides - chemistry, Indicators and Reagents, Kinetics, Leishmania - chemistry, Models, Molecular, molecular dynamics, molecular recognition, Oligonucleotides - chemistry, Spectrometry, Fluorescence, Thermodynamics