Details

Autor(en) / Beteiligte

• MARTINEZ-ABUNDIS, Esperanza
• MOLINA-VILLA, Carlos Alejandro
• GONZALEZ-ORTIZ, Manuel
• ROBLES-CERVANTES, José Antonio
• SAUCEDO-ORTIZ, José Antonio

Titel

Effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity

Ist Teil von

• Annals of plastic surgery, 2007-04, Vol.58 (4), p.416-419

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of this study was to identify the effect of surgically removing subcutaneous fat by abdominoplasty on leptin concentrations and insulin sensitivity. An open clinical trial with a noninterventional parallel group was carried out in 12 obese women. After randomization, 6 volunteers were selected for abdominoplasty, and the other 6 women were considered as the noninterventional group. A metabolic profile, including leptin concentrations, and insulin tolerance test to assess insulin sensitivity were performed on all volunteers before intervention or nonintervention and 40-50 days afterward. A significant reduction in body mass index (30.7 +/- 0.9 versus 29.6 +/- 0.7 kg/m; P = 0.02) and in leptin concentrations (41.3 +/- 10.6 versus 32.0 +/- 10.2 ng/mL; P = 0.02) was observed after abdominoplasty. Insulin sensitivity did not change after intervention. In conclusion, surgically removing subcutaneous fat by abdominoplasty decreased leptin concentrations, with no change in insulin sensitivity.