Details

Autor(en) / Beteiligte

• McIntyre, Dan C.
• Gilby, Krista L.

Titel

Mapping seizure pathways in the temporal lobe

Ist Teil von

• Epilepsia (Copenhagen), 2008-03, Vol.49 (s3), p.23-30

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2008

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Summary Interest in temporal lobe seizure pathways has a long history based initially on the human condition of temporal lobe epilepsy (TLE). This interest in TLE has extended more recently into explorations of experimental models. In this review, the network structures in the temporal lobe that are recruited in animal models during various forms of limbic seizures and status epilepticus are described. Common to all of the various models is recruitment of the parahippocampal cortices, including the piriform, perirhinal, and entorhinal areas. This cortical involvement is seen in in vitro and in vivo electrophysiological recordings throughout the network, in trans‐synaptic neuroplastic changes in associated network structures manifest at the molecular level, in network energy utilization visualized by 14C 2‐deoxyglucose uptake, and finally, in the behavioral consequences of network lesions. The conclusions of the animal models reviewed here are very similar to those described for the human condition presented recently in the 2006 Lennox lecture by Warren Blume, and addressed 53 years ago in the quadrennial meeting of the ILAE in 1953 by Henri Gastaut.