The Plant journal : for cell and molecular biology, 2008-03, Vol.53 (5), p.705-716
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Degradation of the cyclin‐dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases
- Ist Teil von
- The Plant journal : for cell and molecular biology, 2008-03, Vol.53 (5), p.705-716
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Summary In animals and fungi, a group of proteins called the cyclin‐dependent kinase inhibitors play a key role in cell cycle regulation. However, comparatively little is known about the role of these proteins in plant cell cycle regulation. To gain insight into the mechanisms by which the plant cell cycle is regulated, we studied the cyclin‐dependent kinase inhibitor KRP1 in Arabidopsis. KRP1 interacts with the CDKA;1/CYCD2;1 complex in planta and functions in the G1–S transition of the cell cycle. Furthermore, we show that KRP1 is a likely target of the ubiquitin/proteasome pathway. Two different ubiquitin protein ligases, SCFSKP2 and the RING protein RKP, contribute to its degradation. These results suggest that SCFSKP2b and RPK play an important role in the cell cycle through regulating KRP1 protein turnover.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-7412eISSN: 1365-313XDOI: 10.1111/j.1365-313X.2007.03370.xTitel-ID: cdi_proquest_miscellaneous_70332743
- Format
- –
- Schlagworte
- Arabidopsis, Arabidopsis - enzymology, Arabidopsis - genetics, Arabidopsis - metabolism, Arabidopsis Proteins - genetics, Arabidopsis Proteins - metabolism, Biological and medical sciences, Botany, Cell cycle, Cell Cycle - physiology, Cell kinetics, Cell physiology, Cyclin-Dependent Kinase Inhibitor Proteins - genetics, Cyclin-Dependent Kinase Inhibitor Proteins - metabolism, Cyclin-Dependent Kinases - antagonists & inhibitors, Flowers & plants, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Plant, Indoleacetic Acids, Kinases, KRP ubiquitin, Plant physiology and development, Plants, Genetically Modified, Proteins, S-Phase Kinase-Associated Proteins - genetics, S-Phase Kinase-Associated Proteins - metabolism, Ubiquitin-Protein Ligases - metabolism