Details

Autor(en) / Beteiligte

• Revishchin, A.V.
• Korochkin, L.I.
• Okhotin, V.E.
• Pavlova, G.V.
• Jeon, Kwang W

Titel

Neural Stem Cells in the Mammalian Brain

Ist Teil von

• International Review of Cytology, 2008, Vol.265, p.55-109

Ort / Verlag

United States: Elsevier Science & Technology

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• New fundamental results on stem cell biology have been obtained in the past 15 years. These results allow us to reinterpret the functioning of the cerebral tissue in health and disease. Proliferating stem cells have been found in the adult brain, which can be involved in postinjury repair and can replace dead cells under specific conditions. Numerous genomic mechanisms controlling stem cell proliferation and differentiation have been identified. The involvement of stem cells in the genesis of malignant tumors has been demonstrated. Neural stem cell tropism toward tumors has been shown. These findings suggest new lines of research on brain functioning and development. Stem cells can be used to develop radically new treatments of neurodegenerative and cancer diseases of the brain.