Details

Autor(en) / Beteiligte

• Chang, Luan-Yin
• Huang, Li-Min
• Huang, Yhu-Chering
• Gau, Susan Shur-Fen
• Wu, Yu-Yu
• Hsia, Shao-Hsuan
• Fan, Tsui-Yen
• Lin, Tzou-Yien
• Lin, Kuang-Lin
• Lu, Chun-Yi

Titel

Neurodevelopment and Cognition in Children after Enterovirus 71 Infection

Ist Teil von

• The New England journal of medicine, 2007-03, Vol.356 (12), p.1226-1234

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Enterovirus 71 is a common cause of hand, foot, and mouth disease and encephalitis in Asia and elsewhere. Among 142 children who had enterovirus 71 infection with central nervous system involvement, assessment at 2.9 years after infection revealed poor neurodevelopment and cognitive outcomes for children who had severe central nervous system involvement with cardiopulmonary failure. In most children who had central nervous system involvement alone, neurodevelopment was normal. Enterovirus 71 (EV71) is a cause of hand, foot, and mouth disease and encephalitis. In Bulgaria in 1975, Hungary in 1978, and Malaysia in 1997, large outbreaks of EV71 infection resulted in dozens of deaths. 1 – 3 In Taiwan, the most severe EV71 epidemic to date occurred in 1998. 4 During that epidemic, almost all patients with cardiopulmonary failure died. 4 , 5 In 2000, Taiwan developed a disease-management program to improve the survival rate of patients with the infection. 6 , 7 Although that program led to a reduction of acute mortality, 7 concern about long-term sequelae remains. Neurodevelopment and cognitive function may be affected by . . .