Details

Autor(en) / Beteiligte

• Campiglia, Pietro
• Esposito, Cinzia
• Scrima, Mario
• Gomez-Monterrey, Isabel
• Bertamino, Alessia
• Grieco, Paolo
• Novellino, Ettore
• D'Ursi, Anna Maria

Titel

Conformational stability of Abeta-(25-35) in the presence of thiazolidine derivatives

Ist Teil von

• Chemical biology & drug design, 2007-02, Vol.69 (2), p.111-118

Ort / Verlag

England

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• In the attempt to identify a new lead compound able to modify the conformational preferences of the beta-amyloid peptides, a set of new compounds characterized by a thiazolidine ring linked to several different aryl moieties were synthesized. The ability of these compounds to prevent the beta-amyloid aggregation was evaluated using circular dichroism and nuclear magnetic resonance techniques. Molecular docking procedure allowed an interpretation of spectroscopic in the key of molecular interaction.