Details

Autor(en) / Beteiligte

• Lapolla, Annunziata
• Dalfrà, M. G.
• Spezia, R.
• Anichini, R.
• Bonomo, M.
• Bruttomesso, D.
• Di Cianni, G.
• Franzetti, I.
• Galluzzo, A.
• Mello, G.
• Menato, G.
• Napoli, A.
• Noacco, G.
• Parretti, E.
• Santini, C.
• Scaldaferri, E.
• Scaldaferri, L.
• Songini, M.
• Tonutti, L.
• Torlone, E.
• Gentilella, R.
• Rossi, A.
• Valle, D.

Titel

Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience

Ist Teil von

• Acta diabetologica, 2008-03, Vol.45 (1), p.61-66

Ort / Verlag

Milan: Springer Milan

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Some studies have shown that fetal outcome observed in patients using insulin lispro is much the same as in pregnant women using regular insulin. This study aims to analyze the Italian data emerging from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy, comparing those treated with insulin lispro for at least 3 months before and 3 months after conception with those treated with regular insulin. The data collected on pregnant women with diabetes attending 15 Italian centers from 1998 to 2001 included: HbA1c at conception and during the first and third trimesters, frequency of severe hypoglycemic episodes, spontaneous abortions, mode and time of delivery, fetal malformations and mortality. Seventy-two diabetic pregnancies treated with lispro and 298 treated with regular insulin were analyzed, revealing a trend towards fewer hypoglycemic episodes in the former, who also had a significantly greater reduction in HbA1c during the first trimester. The rate of congenital malformations was similar in the offspring of the two groups of women treated with insulin lispro or regular insulin. These findings suggest that insulin lispro could be useful for the treatment of hyperglycemia in type 1 diabetic pregnant women.