Details

Autor(en) / Beteiligte

• Chang, Kenneth J
• Lee, John G
• Holcombe, Randall F
• Kuo, Jeffrey
• Muthusamy, Raman
• Wu, Mark L

Titel

Endoscopic ultrasound delivery of an antitumor agent to treat a case of pancreatic cancer

Ist Teil von

• Nature clinical practice. Gastroenterology & hepatology, 2008-02, Vol.5 (2), p.107-111

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A 72-year-old white male presented to a University Digestive Disease Center with epigastric pain and weight loss. A CT scan suggested that the patient had a mass in his pancreas and he was referred for further diagnostic work-up, staging and treatment. Endoscopic ultrasound (EUS), EUS-guided fine-needle aspiration. Locally advanced, unresectable adenocarcinoma of the pancreas. Opioid analgesics and EUS-guided celiac neurolysis (transgastric injection of bupivacaine and alcohol on both sides of the celiac artery) for pain relief. Five once-weekly intratumoral injections of TNFerade (GenVec, Inc., Gaithersburg, MD) by EUS-guided fine needle injection, in combination with chemoradiation (5 FU/XRT), as part of a multicenter clinical trial. Repeat fine-needle aspiration followed by surgical resection of the tumor.