Cancer cell, 2008-02, Vol.13 (2), p.153-166
2008
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- Autor(en) / Beteiligte
- Titel
- Significance of CD90 + Cancer Stem Cells in Human Liver Cancer
- Ist Teil von
- Cancer cell, 2008-02, Vol.13 (2), p.153-166
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2008
- Quelle
- EZB-FREE-00999 freely available EZB journals
- Beschreibungen/Notizen
- This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90 + cells, but not the CD90 − cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45 −CD90 + population, which could generate tumor nodules in immunodeficient mice. The CD90 +CD44 + cells demonstrated a more aggressive phenotype than the CD90 +CD44 − counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90 + cells. Differential gene expression profiles were identified in the CD45 −CD90 + and CD45 −CD90 − cells isolated from tissue and blood samples from liver cancer patients and controls.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1535-6108eISSN: 1878-3686DOI: 10.1016/j.ccr.2008.01.013Titel-ID: cdi_proquest_miscellaneous_70260817
- Format
- –
- Schlagworte
- Animals, Apoptosis, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - pathology, Cell Line, Tumor, Cell Separation, CELLCYCLE, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Hyaluronan Receptors - metabolism, Leukocyte Common Antigens - metabolism, Liver Neoplasms - genetics, Liver Neoplasms - pathology, Male, Mice, Mice, Nude, Neoplasm Transplantation, Neoplastic Stem Cells - metabolism, Neoplastic Stem Cells - pathology, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, STEMCELL, Thy-1 Antigens - metabolism