Details

Autor(en) / Beteiligte

• Chen, Y.-W
• Umeda, M
• Nagasawa, T
• Takeuchi, Y
• Huang, Y
• Inoue, Y
• Iwai, T
• Izumi, Y
• Ishikawa, I

Titel

Periodontitis May Increase the Risk of Peripheral Arterial Disease

Ist Teil von

• European journal of vascular and endovascular surgery, 2008-02, Vol.35 (2), p.153-158

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Objectives The aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (PAD). Subjects and Methods Twenty-five patients diagnosed with aorto-iliac and/or femoro-popliteal occlusive disease and thirty-two generally healthy control subjects were enrolled in this study. Polymerase chain reaction (PCR) was used to identify Porphyromonas gingivali s, Treponema denticola, Actinobacillus actinomycetemcomitans , Prevotella intermedia, Cytomegalovirus (CMV), Chlamydia pneumoniae , and Helicobacter pylori in tissue specimens taken from the anastomotic site of distal bypasses. Periodontal status was evaluated; serum IgG titres against the four listed bacteria were measured. Results Periodontopathic bacteria were detected in 13/25 (52%) atherosclerotic specimens. CMV or C. pneumoniae was detected in 1/25 (4%) specimens; H. pylori was not detected from any of these specimens. Fontaine grade III or IV patients showed higher detection frequency of P. gingivalis than Fontaine grade II patients (57.1% vs 22.2%, P = 0.09). After adjusting for age, gender, diabetes and smoking, periodontitis increased 5-fold the risk of having PAD (OR 5.45). There were preliminary indications that periodontitis was associated with increased serum IL-6 and TNF-α concentrations. Conclusions This study suggests that periodontitis may be associated with an increased risk of PAD. This association could result from the increased concentration of serum inflammatory cytokines in those with periodontitis.